Zinc Oxide–Graphene Nanocomposite-Based Sensor for the Electrochemical Determination of Cetirizine

A nanocomposite electrode of graphene (Gr) and zinc oxide (ZnO) nanoparticles was fabricated to study the electrochemical oxidation behavior an anti-inflammatory drug, i.e., cetirizine (CET). The voltametric response CET for bare CPE, Gr/CPE, ZnO/CPE, ZnO-Gr studied. modifier materials were characterized using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), powder diffraction (XRD) comprehend surface morphology utilized modifiers. influence pH, scan rate, accumulation time on electrooxidation examined. It found that diffusion-controlled, in which two protons electrons participated. detection limit be 2.8 × 10?8 M a linearity range 0.05–4.0 µM. Study excipients also performed, it they had negligible interference with peak potential CET. validation utility sensor material examined by analyzing clinical biological samples. Stability testing conducted assess reproducibility, determining developed biosensor has good stability high efficiency producing reproducible results.